Guidance

A strategy for testing of chemicals for genotoxicity

Five guidance statements on testing chemicals with no or inadequate genotoxicity data.

• From: Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment
• Published: 1 December 2011
• Last updated: 22 December 2021 — See all updates

Documents

Guidance on a strategy for genotoxicity testing of chemicals

Ref: Ref COM/G strategy – Version 4.0 (2021)

PDF, 562 KB, 74 pages

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Guidance on a strategy for genotoxicity testing of chemical substances: prescreening considerations

Ref: Ref COM/G0 – Version 2.0 (2021)

PDF, 86.7 KB, 3 pages

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Guidance on a strategy for genotoxicity testing of chemical substances: in vitro assessment

Ref: Ref COM/G1 – Version 2.0 (2021)

PDF, 382 KB, 38 pages

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Guidance on a strategy for genotoxicity testing of chemical substances: in vivo testing

Ref: Ref COM/G2 – Version 2.0 (2021)

PDF, 325 KB, 32 pages

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Guidance on mutagenic hazard assessment and a strategy for genotoxicity testing of chemicals with inadequate genotoxicity data

PDF, 67.8 KB, 10 pages

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Details

These statements set out the recommendations of the Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (COM). They include:

• a 3-stage strategy for testing chemicals with no existing genotoxicity data
  • recommendations for stage 0: prescreening considerations prior to testing
  • recommendations for stage 1: a strategy for in vitro assessment
  • recommendations for stage 2: a strategy for in vivo testing
• a final stage of recommendations for chemicals with inadequate genotoxicity data

Published 1 December 2011
Last updated 22 December 2021 + show all updates

1. 22 December 2021

   Updated guidance documents.

2. 1 December 2011

   First published.