Guidance

Carcinogenic dose response: defining points of departure and potency estimates

A statement from the Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC).

• From: Public Health England
• Published: 29 September 2014
• Last updated: 16 December 2020 — See all updates

Documents

Defining a point of departure and potency estimates in carcinogenic dose response

Ref: COC/G 05 – Version 2 (2020)

PDF, 338 KB, 22 pages

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Details

This document describes:

• how to derive points of departure (POD) such as the Benchmark Dose (BMD) and potency estimates, such as the T25 and TD50
• how to use these measures to estimate the relative potency of carcinogens

Published 29 September 2014
Last updated 16 December 2020 + show all updates

1. 16 December 2020

   Added version 2 (2020).

2. 23 May 2019

   Updated with latest version of document.

3. 29 September 2014

   First published.