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Non-tech. summaries 2015: projects on the immune system

Projects granted during 2015 that have a primary purpose of basic research: immune system.

• From: Home Office
• Published: 24 June 2016

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Non-technical summaries: projects granted in 2015, volume 23

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2015 with a primary purpose of basic research: immune system.

The following projects were granted:

• provision of blood, tissues and antisera (provision of biological materials)

• stem cells for blood and tissue repair (blood, blood vessel, repair, transplantation, regeneration)

• kinetics, dynamics & diagnostics of CB agents & antidotes (pharmacokinetic; pharmacodynamic; toxicokinetic; toxicodynamic, antidotes)

• repopulation of the blood system in zebrafish (haematopoiesis, haematopoietic stem cells (HSCs), zebrafish)

• restoring control of immune responses in the retina (retina, immune, responses, restoring, control)

• drug and vaccine formulation and delivery (drug delivery, vaccines, formulation)

• novel vaccine platforms targeting chronic disease (vaccination, chronic disease, VLPs, immunotherapy)

• immune responses to persistent herpesviral infection (memory inflation, cytomegalovirus, adenoviruses, vaccine)

• the immune response in wound healing and cancer (inflammation; wound healing; cancer; mice; zebrafish)

• the causes and treatment of autoimmune diabetes (diabetes, insulin, immune system)

• intrinsic & extrinsic effects on B cell responses (B cells, vaccination, mice, antibody)

• biology of carbohydrate-binding proteins (immunology, cell biology, glycobiology)

• parameters of macrophage origin and function (macrophage, ontogeny, stem cell, inflammation)

• immunology of cancer and pregnancy (immunity, pregnancy, cancer, transgenes, mice)

• mechanisms of T cell survival and homeostasis (t lymphocyte, homeostasis, cancer, mice)

• physiological regulation of innate immune responses (myeloid cell, inflammation, hypoxia, metabolism, mice)

• molecular regulation of the immune response (inflammation, cancer, viral infection, immunology)

• regulation of immunity, inflammation and haematopoiesis (immunity, asthma, infection, cytokines, haematopoiesis)

• mouse antibodies for biomedical research (immunisation mouse antibody adjuvant)

• finding curative therapies for blood cancers (blood, haematology, stem cells, blood cancer)

• blocking autoimmunity by targeting CD4 T cells (autoimmunity, CD4 T cells, tregs, OX40)

• phagocyte function and inflammatory bowel disease study (bacteria, crohn’s disease, neutrophil, granulomatous)

• EGFR mediated modulation of immune responses (inflammation, immune regulation, tissue remodelling, protection against pathogens and wound repair)

• modulators of immunity and inflammation (infection, therapy, autoimmunity, allergy, cancer)

• the role of B cells and microbiota in autoimmunity (autoimmunity, B cells, gut-bacteria)

• evaluating candidate HIV/AIDS vaccine strategies (HIV, vaccines, pathogenesis)

• molecular networks of inflammation (immunology, inflammation, autoimmunity, signalling)

• production of blood products (animal infection antisera)

• pathophysiology of autoimmune diseases (autoimmune disease, immune molecules)

• investigating the immune response to somatic corneal stem cell allografts (cornea, stem cell, immune system, transplantation, graft rejection)

• impacts of urban development on avian immune systems and disease (immune response; blackbirds; turdus merula; urbanisation)

• an ecological approach to infection and immunity (ecology, coinfection, immunity, helminths, wild mice)

• initiation, resolution and modulation of inflammation (autoimmunity; allergy; inflammation; T cells; therapy)

• type 2 immunity in infection and tissue homeostasis (helminth infection, cytokines, macrophages, wound repair, allergy)

• does steroid production in inflammatory arthritis cause joint destruction, muscle wasting and bone loss? (rheumatoid arthritis, steroid metabolism, bone loss, muscle wasting, cartilage erosion)

• polarised secretion from lymphocytes (immune cells, cancer, viral infections)

• neonatal bacterial meningitis – infection and treatment (in vivo imaging; escherichia coli K1; blood-brain barrier; group B streptococcus; neonatal bacterial meningitis)

• immune responses promoting inflammatory disorders (innate immunity, cancer , inflammation, imaging)

• production of hymenolepis diminuta ova in rats (hymenolepis diminuta ova rat tapeworm)

• drug assessment in models of multiple sclerosis (multiple sclerosis, therapy, immunology, demyelination, remyelination)

• enhancing the value of selective breeding for parasite resistance (parasitology, livestock, genetics, immunology, pathology)

• pathogenesis mechanisms of bacterial pathogens (macrophages, innate immunity, listeria, streptococci, staphylococci)

• the production of antibodies (antibody, polyclonal, monoclonal, immunogen, antigen)

• mechanisms of lymphocyte activation (lymphocyte, immunoresponse)

• the immune system as gateway for mental and physical wellbeing (emotion, immune-response, translational medicine)

• mice with human immune systems for drug discovery (human immunoglobulins, vaccines, mice, T-cell-receptor)

• regulation of the immune response in tissues (immune response, infection, cellular immunotherapy)

• inflammation and immunity in digestive diseases (inflammation liver gut pancreas)

• the role of circadian clocks in immunity (circadian, inflammation, lung, glucocorticoids, parasites)

• immune responses in helicobacter infections (immune, responses, helicobacter, infections)

• perturbations of adaptive immunity in inflammatory arthritis (immune response, arthritis, cell migration, inflammation)

• regulation of immune responses in health and disease (inflammation, cytokines, infection, repair, autoimmunity)

• neutrophil function in infection and disease (inflammation, cytokines, infection, autoimmunity, neutrophils)

• NF-κB and MAP kinase signalling in immunity and cancer (autoimmunity; inflammation; cancer; mechanisms; therapy)

• the production of antibodies (antibody, polyclonal, monoclonal, immunogen, antigen)

• understanding how vaccines work (vaccine, infection, natural killer (NK) cells, T-cells, ageing)

Published 24 June 2016