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Non-tech summaries 2016: projects on cardiovascular disorders

Projects granted during 2016 that have a primary purpose of translational applied research - human cardiovascular disorders.

• From: Home Office
• Published: 21 December 2017

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Non-technical summaries: projects granted in 2016, volume 18

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of translational applied research - human cardiovascular disorders.

The following projects were granted:

• analysing signalling gene function in the heart (heart, electrophysiology, hypertrophy, arrhythmias)

• mechanisms of innate immunity in cardiovascular disease (heart disease, immune system)

• prevention of chronic heart failure (heart failure, myocardial infarction, diabetes, hypercholesterinaemia)

• genetic and bioenergetic determinants of cardiac arrhythmias (arrhythmias, heart disease, sudden death, genetics)

• autonomic control of the cardiovascular system (cardiovascular disease, autonomic control)

• the effects of myocardial infarction (myocardial infarction)

• preclinical therapies for pulmonary hypertension (cardiovascular, pulmonary, genetics, therapy)

• pathophysiology of the cardiovascular system (metabolic syndrome; obesity; heart function; atherosclerosis)

• comparative cardiovascular homeostasis (transgenics; hypertension; metabolism; kidney)

• mechanisms of progressive cardiac dysfunction (heart failure, hypertrophy, cardiac remodelling)

• pathophysiology of heart failure (heart failure, calcium, β-adrenergic, ultrastructure)

• cardiac injury, repair, regeneration & remodelling (heart attack, drug therapy, heart failure)

• dietary vascular protection in utero and stroke (stroke, obesity, pregnancy, risk, diabetes)

• mechanisms of thrombosis and atherosclerosis (macrophages, endothelial cells, inflammation, atherosclerosis, thrombosis, cardiovascular disease)

• investigating the genetics of cardiovascular disease (hypertension, organ-damage, rats, mice, genetics)

• investigating a novel treatment for heart failure (perhexiline, metabolism, hypertrophy, heart failure)

• small animal models of cardiovascular disease (ischaemia, therapy, cardiovascular disease)

• regulation of thrombosis and haemostasis and its influence on cardiovascular diseases (clot, thrombosis, stroke, atherosclerosis, vessel wall)

• pathogenesis and therapy of vascular diseases (atherosclerosis; aneurysm; angiogenesis; cell therapy; cardiovascular diseases intervention.)

• rodent models of arteriosclerosis (arteriosclerosis, stem cells, endothelial cells, vessel graft)

• role of nitric oxide and reactive oxygen species in cardiac function (nitric oxide, reactive oxygen species, heart failure, diabetes, atrial fibrillation)

• rodent models of pulmonary hypertension and associated co-morbidities (pulmonary hypertension, pulmonary vascular remodelling, right heart failure)

• vascular protective genes in angiogenesis (vascular, preeclampsia, hydrogen sulphide, heme oxygenase, pregnancy)

• myocardial infarction and heart failure (heart, failure, infarction, protection, injury)

• angiogenesis, microcirculation and microenvironment (angiogenesis, microcirculation, tumour growth, wound-healing, vascular-targeted)

• protecting and repairing the diseased heart (heart attack, cardiac surgery, ischemia reperfusion injury)

• factors affecting valve development and disease (veins, lymphatics, heart)

• studies of complex genetic traits in rats (rat, cardiovascular, metabolic, kidney genetics)

• mechanistic studies in pre-clinical stroke/small vessel disease (stroke, small vessel disease, hypertension, rats, mice)

• understanding and treating cardiovascular disease (cardiovascular development, heart repair)

• the molecular basis of cardio-metabolic disease (diabetes, cardiovascular disease, insulin resistance, insulin-like growth factors, atherosclerosis)

• myocardial infarction (heart attack, vascular dysfunction, nitrite, nitric oxide, perhexiline)

• calcium-permeable channels and their associated mechanisms and therapeutic potential (blood vessel, cardiovascular disease, cancer, diabetes, calcium channels)

• improving minimally invasive treatment of coronary artery disease (coronary, artery, atherosclerosis, angioplasty, stents)

• targeting the immune response in cardiovascular diseases (atherosclerosis; restenosis; aneurysm; myocardial infarction; stroke)

• innovative treatments for heart failure (heart failure, stem cell therapy, gene therapy, drug therapy)

• ischaemia-reperfusion injury and shock (ischaemia, shock, kidney, haemorrhage, heart research, trauma)

• the long-term effects of prenatal hypoxia on cardiomyocyte function (programming, pre-natal hypoxia, cardiac, mitochondria, myocyte)

Published 21 December 2017