Research and analysis

NOIDs causative agents: week 45 (week ending 10 November 2024)

Updated 23 December 2024

Applies to England and Wales

Laboratories in England have a statutory duty to notify the UK Health Security Agency of the identification of the following causative agents:

  • Bacillus anthracis
  • Bacillus cereus
  • Bordetella pertussis
  • Borrelia spp
  • Brucella spp
  • Burkholderia mallei
  • Burkholderia pseudomallei
  • Campylobacter spp
  • Carbapenemase-producing Gram-negative bacteria
  • Chikungunya virus
  • Chlamydophila psittaci
  • Clostridium botulinum
  • Clostridium perfringens
  • Clostridium tetani
  • Corynebacterium diphtheriae
  • Corynebacterium ulcerans
  • Coxiella burnetii
  • Crimean-Congo haemorrhagic fever virus
  • Cryptosporidium spp
  • Dengue virus
  • Ebola virus
  • Entamoeba histolytica
  • Escherichia coli O 157
  • Francisella tularensis
  • Giardia spp
  • Guanarito virus
  • Haemophilus influenzae (invasive)
  • Hanta virus
  • hepatitis A
  • hepatitis B
  • hepatitis C
  • hepatitis D
  • hepatitis E
  • influenza virus
  • Junin virus
  • Kyasanur Forest disease virus
  • Lassa virus
  • Legionella spp
  • Leptospira interrogans
  • Listeria monocytogenes
  • Machupo virus
  • Marburg virus
  • Measles virus
  • mpox virus
  • mumps virus
  • Mycobacterium tuberculosis complex
  • Neisseria meningitidis
  • Omsk haemorrhagic fever virus
  • Plasmodium falciparum
  • Plasmodium Knowlesi
  • Plasmodium Malariae
  • Plasmodium Ovale
  • Plasmodium Vivax
  • polio virus
  • Rabies virus
  • Rickettsia spp
  • Rift Valley fever virus
  • Rubella virus
  • Sabia virus
  • Salmonella spp
  • SARS coronavirus
  • Shigella spp
  • Streptococcus group A (invasive)
  • Streptococcus pneumoniae (invasive)
  • Varicella zoster virus
  • Variola virus
  • Vibrio cholerae
  • West Nile virus
  • Yellow fever virus
  • Yersinia pestis

Statutory notifications of causative agents, grouped by root organism

Totals for the current week compared to the previous 5.

Week notification received 2024/40 2024/41 2024/42 2024/43 2024/44 2024/45
Bacillus            
Bacillus cereus 10 24 19 8 13 12
Bordetella            
Bordetella pertussis 61 53 77 52 53 39
Borrelia            
Borrelia burgdorferi 51 31 26 37 49 39
Borrelia sp 5 10 3 8 3 5
Brucella            
Brucella melitensis 1 - - - - 1
Brucella sp 2 - - 2 - 5
Campylobacter            
Campylobacter coli 45 34 27 34 56 37
Campylobacter fetus 2 - 3 - - 2
Campylobacter jejuni 316 343 368 285 373 308
Campylobacter other named 3 2 4 - 1 5
Campylobacter rectus - 1 1 - - -
Campylobacter sp 1,278 1,266 1,141 921 1,361 1,165
Campylobacter upsaliensis - 1 1 - - -
Campylobacter ureolyticus (bacteroides corrodens) - 2 1 1 1 -
Chikungunya virus            
Chikungunya virus 4 1 4 - - 1
Clostridium            
Clostridium perfringens 21 31 32 23 55 34
Coronavirus            
Coronavirus 14 25 15 29 34 32
Human coronavirus 229e - - 1 - 1 2
SARS coronavirus - - - - - 1
SARS-CoV-2 antibody indeterminate 71 73 53 75 95 78
SARS-CoV-2 antibody void 4 2 2 3 - 2
SARS-CoV-2 coronavirus (COVID-19) 3,046 3,606 3,003 2,375 2,365 1,596
SARS-CoV-2 coronavirus (COVID-19) indeterminate 104 100 83 49 96 80
SARS-CoV-2 IgG antibody negative 19 18 10 9 32 10
SARS-CoV-2 IgG antibody positive 98 118 118 89 144 103
SARS-CoV-2 total antibody negative 13 21 16 1 4 20
SARS-CoV-2 total antibody positive 61 54 58 35 51 44
Corynebacterium            
Corynebacterium diphtheriae 2 2 2 1 2 5
Corynebacterium ulcerans - - 1 - - -
Coxiella            
Coxiella burnetii - 1 - - - -
Cryptosporidium            
Cryptosporidium cuniculus 1 1 - - 1 -
Cryptosporidium hominis 24 27 27 32 33 15
Cryptosporidium meleagridis - - - - 1 -
Cryptosporidium parvum 44 28 63 53 52 24
Cryptosporidium sp 73 68 38 41 55 109
Cryptosporidium ubiquitum 1 - 1 - 1 -
Entamoeba            
Entamoeba histolytica 3 1 1 - - 1
Escherichia            
Escherichia coli O 157 14 17 13 9 11 11
Flaviviruses            
Dengue virus 1 2 6 8 2 5
Francisella            
Francisella tularensis - - - - 1 -
Giardia            
Giardia sp 110 119 116 102 128 98
Haemophilus            
Haemophilus influenzae 58 48 58 55 69 77
Hepatitis viruses            
Hepatitis A 33 29 25 21 17 10
Hepatitis B 332 277 279 258 352 247
Hepatitis C 284 248 283 262 351 251
Hepatitis D 10 9 13 6 11 6
Hepatitis E 47 31 28 34 44 32
Influenza virus            
Influenza A 450 519 581 590 1,455 819
Influenza B 71 56 75 78 144 80
Influenza indeterminate 4 - - 8 - -
Influenza ungrouped 4 12 34 29 24 16
Legionella            
Legionella longbeachae 1 - - 1 - 1
Legionella pneumophila 7 10 11 3 15 8
Legionella sp 4 4 3 1 3 5
Leptospira            
Leptospira interrogans - - 1 1 - -
Listeria            
Listeria monocytogenes 3 2 2 4 13 7
Mycobacterium            
Mycobacterium tuberculosis 95 104 81 107 95 100
Neisseria            
Neisseria meningitidis 21 28 34 31 33 49
Orthopoxvirus            
Mpox virus 5 4 3 1 20 5
Paramyxoviruses            
Measles virus 12 8 12 12 24 21
Mumps virus 5 7 6 1 8 3
Plasmodium            
Plasmodium falciparum - 17 - - - 10
Plasmodium malariae - 1 - - - -
Plasmodium ovale - 1 - - - 2
Plasmodium vivax - 4 - - - 2
Polyomavirus            
Polyomavirus BK 46 75 57 66 66 64
Polyomavirus JC 8 8 4 9 6 9
Polyomavirus untyped 10 18 28 7 22 16
Rickettsia            
Rickettsia spotted fever - - 1 - 1 1
Rubella virus            
Rubella virus 2 1 2 3 4 -
Salmonella            
Other salmonellas 81 90 84 73 53 23
Salmonella blockley 7 - - - - -
Salmonella bovis-morbificans - 5 - - - -
Salmonella braenderup 5 - - - - -
Salmonella chester - - - 7 - -
Salmonella enterica - 5 6 - - 6
Salmonella enteritidis 115 111 93 64 88 22
Salmonella infantis - - 7 - - -
Salmonella java 10 - - 6 - -
Salmonella kentucky 10 - - - - -
Salmonella mikawasima 11 15 18 10 18 -
Salmonella newport 6 - 8 7 - -
Salmonella sp 45 35 37 25 98 189
Salmonella typhi and paratyphi 28 15 16 12 6 10
Salmonella typhimurium 50 34 41 40 24 17
Salmonella virchow 7 - - - - -
Salmonella enterica 7 11 5 - 10 5
Shigella            
Shigella boydii 2 - 4 1 - 1
Shigella dysenteriae - - - - 1 -
Shigella flexneri 19 22 28 13 15 7
Shigella sonnei 24 31 25 12 28 16
Shigella sp 59 62 60 50 81 83
Streptococcus            
Streptococcus group A 41 43 62 30 38 49
Streptococcus pneumoniae 89 111 107 128 138 138
Vibrio            
Vibrio cholerae 3 2 1 1 1 3

Carbapenemase-producing Enterobacterales (CPE)

For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.

Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.

Week notification received 2024/40 2024/41 2024/42 2024/43 2024/44 2024/45
Citrobacter              
Citrobacter spp IMP 1 1 1 - 1 -
  KPC 2 1 3 1 - -
  NDM 4 2 1 - - -
  OXA48 5 3 1 1 - 1
  VIM 3 - - - - -
Cronobacter              
Cronobacter sakazakii KPC - - 1 - - -
  NDM - - 1 - - -
Enterobacter              
Enterobacter cloacae complex IMP 3 1 3 8 1 -
  KPC 8 3 7 6 7 3
  NDM 14 6 8 11 8 -
  OXA48 6 2 3 6 4 2
  VIM 1 - - - - -
  Other 1 1 - 3 1 1
Other enterobacter spp IMP 1 - - - 1 -
  KPC 1 - - - - -
  NDM 1 2 1 - - -
  OXA48 - 1 - - 2 -
Escherichia              
Escherichia coli IMP - - 1 1 1 -
  KPC 1 3 3 3 4 -
  NDM 21 17 14 12 10 6
  OXA48 18 17 20 29 17 8
  VIM 1 - - - - -
  Other 3 2 2 - 1 -
Escherichia hermannii NDM 1 - - - - -
Klebsiella              
Klebsiella aerogenes NDM 1 - - 1 - -
  OXA48 - - - 1 - 1
Klebsiella oxytoca IMP - 2 - - 1 -
  KPC 2 1 2 - 2 2
  NDM - 4 - 1 1 -
  OXA48 1 1 1 2 3 -
Klebsiella pneumoniae IMP 5 1 3 3 2 -
  KPC 17 11 14 14 10 2
  NDM 8 14 7 14 8 1
  OXA48 10 13 10 17 7 1
  VIM 2 - - - - -
  Other 1 1 2 - 1 -
Klebsiella variicola KPC - 1 2 - - -
Other klebsiella spp KPC - - - 1 - -
  OXA48 1 - - 1 - -
Leclercia              
Leclercia adecarboxylata KPC - - - - 1 -
Morganella              
Morganella morganii NDM - 1 - - - -
  OXA48 - 1 - - - -
  Other - - - - 1 -
Pantoea              
Pantoea septica KPC 1 - - - 1 -
  NDM 1 - - - 1 -
Proteus              
Proteus mirabilis NDM 3 - 2 2 - -
  OXA48 - 1 - - - -
  Other 1 1 2 2 - 1
Providencia              
Providencia stuartii NDM 1 - - - - -
  OXA48 - - 1 - - -
  Other - - 1 - - -
Raoultella              
Raoultella planticola (klebsiella planticola) OXA48 - 1 - - - -
Serratia              
Serratia marcescens/ureilytica NDM - - - 1 - -

Other carbapenemase-producing Gram-negative organisms

For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.

Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.

Week notification received 2024/40 2024/41 2024/42 2024/43 2024/44 2024/45
Acinetobacter              
Acinetobacter baumannii NDM - 1 - 1 2 -
  Other 1 1 - - - -
Other acinetobacter spp NDM - - - 1 - 2
Pseudomonas              
Pseudomonas aeruginosa IMP - 1 - - - -
  NDM 3 - - 2 3 -
  VIM 1 1 1 1 1 -
  Other 4 3 1 4 3 -
Pseudomonas fluorescens group Other - - - - 1 -
Other pseudomonas spp Other - - 1 - - -