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Non-tech. summaries 2014: projects on the endocrine system

Projects granted during 2014 that have a primary purpose of basic research into the endocrine system and metabolism.

• From: Home Office
• Published: 25 April 2016

Documents

Non-technical summaries: projects granted in 2014, volume 15

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2014 with a primary purpose of basic research: endocrine system and metabolism.

The following projects were granted:

• regulation of pituitary physiology (pituitary, gene regulation, prolactin)

• genetics of metabolism (diabetes, obesity, diabetic complications, ageing)

• the aetiology of metabolic disorders (diabetes, obesity, insulin secretion, channelopathy)

• islet pretreatment to reduce hypoxic graft damage (diabetes, islets, transplantation, hypoxia)

• oral delivery of test agents (oral gavage, diabetes therapy)

• neuroplasticity, immunity and behaviour (rodent, seasonality, leukocytes, reproduction, neuroangiogenesis)

• metabolic alterations of pregnancy (pregnancy, metabolic disease, offspring, therapies)

• modulation of endocrine pathways by imprinted genes (Imprinting, hormones, development, epigenetics, metabolic)

• relationship between diabetes and cancer (diabetes, cancer, pancreatitis)

• energy homeostasis and metabolism (food intake, energy expenditure, obesity)

• effects of mitochondrial functioning on mammal phenotype (endothermy, BAT, oxidative stress, rodents)

• nuclear envelope roles in health and disease (nuclear envelope, genorne organ isation, metabolism 5 years)

• the role of copper in diabetes and ageing (arteries, kidney, heart, eyes, biomarkers, treatment)

• the role of NPPC in pituitary development (C-type natriuretic peptide (CNP), genetic modification tissue specific, mouse)

• genetic toxicology: chemicals (mutagen, genetic toxicology)

• impact of gut microbiota on type II diabetes (microbiota, metabolism, type II diabetes, obesity)

Published 25 April 2016