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Non-tech. summaries 2015: projects on human cancer

Projects granted during 2015 that have a primary purpose of translational and applied research: projects on human cancer.

• From: Home Office
• Published: 21 June 2016

Documents

Non-technical summaries: projects granted in 2015, volume 15

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2015 with a primary purpose of translational and applied research: projects on human cancer.

It contains a full list of the 22 projects that were granted.

The projects covered are:

• imaging and image-guided therapy (in-vivo, imaging, cancer, mouse)

• functions of dna repair genes in genome stability and cancer (DNA repair, cancer, genome stability)

• mechanisms of brain cancer progression (brain, CNS, cancer, mouse)

• novel immuno-oncology therapies (cancer, tumour, immunotherapies)

• focus on the BRCA1 n-terminus in development and cancer (breast cancer, genetics)

• imaging in drug discovery (non-invasive, medical imaging, drug discovery)

• immunotherapy of cancer (immunology, cancer, vaccine, therapy, cure)

• novel therapies for human cancer (cancer, tumour, drug)

• RAC and RAC regulators in development and cancer (RAC, cancer initiation, metastasis)

• evaluation of novel treatments for prostate cancer (prostate, androgen receptor, n-terminal domain, rotenoid)

• using patient derived xenografts to study cancer (cancer, patient derived xenograft (PDX))

• function of tetraspan complexes in carcinogenesis (tetraspan, integrin, kinase, tumourigenesis, metastasis)

• translational chrono-oncology (biological clocks, cancer, pharmacology)

• identifying and characterising the cellular drivers of adult acute lymphoblastic leukaemia (leukaemia mouse models)

• investigation of normal and aberrant haemopoiesis (haemopoiesis, cancer, bone marrow failure, graft-versus-host disease)

• biology of normal and malignant blood cells (leukaemia, cord blood, fusion gene, cytokine)

• therapeutic antibodies for cancer (monoclonal antibody, immune therapy, cancer)

• in vivo assessment of biomaterials (cancer therapies)

• advanced nucleic acid and small molecule therapies for cancers (nucleic, acid, molecule therapies cancers)

• radiation combinations for cancer treatments (radiation, rodent, cancer)

• evaluation of therapeutics for the treatment of head and neck cancer (head and neck, thyroid, cancer, drug discovery)

• therapeutic strategies to improve organ quality and function in a pig model (transplantation, retrieval, improve organ quality)

Published 21 June 2016