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Non-tech summaries 2016: projects on nervous system

Projects granted during 2016 that have a primary purpose of basic research, nervous system.

• From: Home Office
• Published: 22 December 2017

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Non-technical summaries: projects granted in 2016, volume 3

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This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of basic research, nervous system.

The following projects were granted:

• analysis of neurological mouse mutants (brain, neurodegeneration, psychiatry, behaviour, movement disorders)

• RNA methylation in neurodevelopmental disorders (rna methylation, synaptic plasticity, fragile-x syndrome, autism, schizophrenia)

• autoimmune diseases in the central nervous system (multiple sclerosis, autoimmune disease)

• misfolded proteins in neurodegenerative disease (misfolding, neurodegenerative diseases, proteins)

• mechanisms underlying neurodegeneration (neurodegeneration, alzheimer’s disease, therapeutic, mechanisms)

• imaging agents to investigate epileptogenesis (epilepsy, imaging, radiotracer)

• genes and lifestyle influences on brain ageing (diet, brain, genotype, ageing, inflammation)

• investigating motor neuron disease and dementia (paralysis, dementia)

• nervous system injury and repair strategies (hypoxia-ischaemia, neonatal encephalopathy, CNS injury, PNS injury, oxidative stress)

• development and nervous system repair in zebrafish (brain, spinal cord, injury, regeneration)

• mechanisms of neuronal dysfunction in neurodegeneration (neuronal function, neurodegeneration, nitric oxide toxicity)

• brain mechanisms for learning and decision-making (learning, decision-making, prefrontal cortex, reward)

• development of novel translatable measures and therapeutics for pain disorders (pain, rodents, analgesics, biomarkers, drug discovery)

• mechanisms of neuronal plasticity (alzheimer’s disease, schizophrenia, synapse, genes)

• presynaptic function in health and disease (neurotransmitter, neurone, synapse, vesicle, disease)

• neural plasticity in health and disease (learning, memory, neural development, neurodegeneration)

• development of new models of FTLD/MND (neurodegeneration; dementia; transgenic; mouse; disease)

• roles of electrical activity in brain maturation (brain, activity, plasticity, development, olfaction)

• studies of brain development in the mouse (mouse, brain development)

• bioelectronic medicines (electrophysiology, implantable devices)

• tissue isolation for electrophysiology, neurochemistry and pharmacology (neurodegeneration, pain, native, drug discovery)

• investigation of genetic forms of neurodegeneration (frontotemporal dementia, motor neuron disease, amyotrophic lateral sclerosis, C9orf72)

• autophagy and neurodegeneration (autophagy, neurodegeneration, ataxia, signalling pathways)

• inter-connected studies of prion and other neurodegenerative diseases (prions, creutzfeldt-jakob disease, transgenic, therapeutics)

• cns glial development and demyelinating disease (multiple sclerosis, demyelination, neuroinflammation, neurodegeneration, neuropathology)

• Mechanisms of synaptic transmission and plasticity in the central nervous system (synaptic transmission, learning and memory, ageing, neurodegeneration)

• the role of glia in nerve regeneration and cancer (nerves, cancer, regeneration, glia, microenvironment)

• impact of exercise and NAD levels on brain and fat tissue (voluntary exercise, healthy ageing, epigenetics, NMNAT1, stem cells)

• dorsal horn circuits in normal and pain states (interneurons; circuits; acute pain; chronic pain; mouse)

• assessment of vascular cognitive impairment in rodents (dementia, cognition, vascular risk factors, neuroimaging)

• neural mechanisms of pain and homeostasis (nociception, neuroscience, autonomic nervous system, behaviour)

• mechanisms of acute and chronic pain (inflammation, arthritis, neuropathy, diabetes, 33. understanding cortical plasticity in health and disease)

• understanding cortical plasticity in health and disease (memory, schizophrenia, parietal cortex, prefrontal cortex, mouse)

• triggering and propagation of neurodegeneration (neurodegeneration; parkinson’s disease; ALS; synuclein; RNA-binding proteins)

• cortico-thalamo-cortical interactions in primate cognition (cortex, thalamus, learning, memory, decision-making)

• using transplanted neural tissue to understand neurological disease (neuron, development, brain)

• experimental molecular medicines for restorative neuroimmunology (molecular therapies, inflammation, brain, stem cells, brain repair)

• mechanisms of brain function and dysfunction (neurons, glia, receptors, glutamate, dopamine)

• drug development in tuberous sclerosis complex (tuberous sclerosis, drug development, seizures, tumours, cognition)

• neuron-g lial-pericyte-vascular interactions (neuron, astrocyte, oligodendrocyte, microglia, pericyte)

• synapses and plasticity in health and disease (alzheimer’s disease; learning & memory; diet; improved mouse models)

• genome involvement in brain function, disease and development. (disease, genetics, gene regulation, transgenic, mouse)

• regeneration and cancer in the nervous system (neural stem cells, glioblastoma, tissue environment, injury, repair)

• establishing connectivity in the brain (brain development, neurodevelopmental disorders, vision)

• mechanisms underlying huntington’s disease (behaviour, sleep, circadian rhythms, EEG)

• signalling and neurodegeneration (parkinson’s disease, alzheimer’s disease, disease mechanism, finding new targets for treatment)

• information encoding for memory storage and retrieval in mammalian brain circuits (brain, memory, perception, alzheimer’s disease)

• investigating and modulating cortical network activity (dementia, epilepsy, neurons, brain circuits)

• the function of the neural circuitry of the olfactory bulb (olfactory bulb, smell, neural circuit)

• information processing in neural networks (brain, neural code, multisensory, perception, memory)

• preclinical research of novel pain therapeutics (chronic pain, analgesia, hyperalgesia, allodynia, therapeutics)

• sumoylation accelerates supply-rate depression (epilepsy, SUMOylation, synapsins, levetiracetam)

• mechanisms of brain plasticity in health and disease (neuron, plasticity, learning, memory)

• neurogliaform cells in health and disease (interneuron, neocortex, neural circuits, neurogliaform cells, synaptic neurotransmission)

• mechanisms controlling vertebrate development (neuronal development, axon guidance, vision)

• organisation and function in cerebellar and pre-cerebellar circuits (cerebellum, movement, learning, neurophysiology, motor control)

• interactions between the developing visual and nervous system (eye development, brain development, eye disease, sensory guided behaviour)

• role of gut-brain axis on brain and behaviour (gut-brain, casein, early-life)

• understanding brain function and dysfunction using stroke models (brain, stroke, blood flow, ageing, MRI)

• mechanisms underlying neural development (brain, stem cells, neurogenesis, gliogenesis, transcription factors)

• neural circuit mechanisms for animal behaviour (neuron, brain, cognition, behaviour, navigation)

• understanding and treating neurodegenerative disorders (neurological diseases, mechanisms of disease, new therapies)

• molecular determinants of cortical development (cortex, development, neurogenesis, migration, circuits)

• metabolic and cardiovascular regulation by GLP-1 and the autonomic nervous system (diabetes, obesity, neurophysiology)

• regulation of the circadian clock and sleep homeostasis (sleep, circadian, clock, neuroscience)

• cortical structure and information processing (brain, neurons, synapses, neuronal networks, sensory physiology)

Published 22 December 2017