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Non-tech summaries 2016: projects on nervous/mental disorders

Projects granted during 2016 that have a primary purpose of translational applied research - human nervous and mental disorders.

• From: Home Office
• Published: 21 December 2017

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Non-technical summaries: projects granted in 2016, volume 19

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Details

This document outlines the projects granted under the Animals (Scientific Procedures) Act 1986 during 2016 with a primary purpose of translational applied research - human nervous and mental disorders.

The following projects were granted:

• developing therapies for perinatal diseases (lack of oxygen, brain haemorrhage)

• neurovascular function in health and disease (brain, blood vessels, alzheimer’s disease, energy, pericyte)

• assessment of blood brain barrier transporters (drug discovery; blood brain barrier)

• modulating autophagy tct tackle huntington’s disease (autophagy, cell death, huntington’s disease)

• translational pharmacology for drug discovery (pharmacology, drug, discovery)

• electrophysiological studies of neurodegenerative disorders (neurodegeneration, drug discovery, electrophysiology, in vivo)

• anaesthesia and the developing brain (anaesthesia, neurodegeneration, neuro-apoptosis, developing brain)

• gene transcription events mediating brain and behaviour (epigenetics; post-transcriptional modification; imprinted genes; behaviour; brain)

• examining the role of mitochondria in neurodegeneration and vascular disorders (alzheimers, blood vessels, mitochondria, neurodegeneration)

• using zebrafish to understand disease and develop therapies (zebrafish, development, disability, therapy, mechanism)

• pharmacodynamics and pharmacokinetics of novel compounds (drug discovery, receptor, pharmacokinetic, pharmacodynamic)

• MK2 as a regulator of inflammation in alzheimer’s (alzheimer’s, inflammation, hippocampus, synaptic plasticity, behaviour.)

• neural signalling and disease in rodents (motoneurone, mechanosensation, MND, hypertension)

• repair in neurodegenerative disease and injury (central nervous system, nerve cells, neurodegenerative diseases, regeneration)

• role of D1R-D3R heteromers in l-DOPA-induced dyskinesias (parkinson’s disease, dyskinesia, dopamine, heteromers, glutamate receptors)

• maintenance and regeneration of the nervous system (avulsion, neurodegeneration)

• determination of CNS efficacy and safety pharmacology (central nervous system, behaviour, safety)

• zebrafish and medaka as models for the study of psychiatric disease and age-related cognitive decline (zebrafish, behaviour, addiction, genetic modification, ageing)

• early life exposure to drugs and environmental complexity and neuropsychiatric disorder (genetics, nature/nurture, environmental complexity)

• neurological disorders: mechanisms and therapies (behaviour, cognition, brain, neurological disorder)

• analgesic potential of retargeted SNARE proteases (analgesia, pain, neuropathic, post-operative, inflammatory)

• CNS neurotransmitter action in health and disease (brain, neurodevelopmental disorders, neurodegeneration, neuron, glia)

• improving the treatment of parkinson’s disease and parkinson’s disease dementia (parkinson’s disease, dementia, better treatments, cell protection, cell repair)

• neuropharmacology and therapeutics in addiction and other dopamine-associated disorders (addiction, parkinson’s disease, treatments, neurogenesis)

Published 21 December 2017